Overlaid positive and negative feedback loops shape dynamical properties of PhoPQ two-component system
Fig 5
Combination of positive and negative feedback increases range of sensitivity to signal.
A—steady state response of simulated promoter output (YFP, normalized to high Mg2+ YFP) for models with no positive feedback (black), no negative feedback (green) and both feedback loops (blue). B- Absolute value of sensitivity (log derivative of PhoP-P with respect to k−1, ) for model with no negative feedback (green) has the shortest range of signal sensitivity, while the wild-type model displays two phases of high sensitivity to signal.