Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis
Fig 4
Intra- vs. extracellular bacterial load in TB infection.
Intra- and extracellular bacteria count in lung tissue for TB infection with standard drug therapy (2HREZ/4HR). The TB infection occurs on day -180, and drug therapy is started on day 0, triggering rapid intra- and extracellular bacterial death. The grey shaded block represents the cut-off of CFU/ml equal to 1 for a patient to be considered cleared of bacteria at the end of treatment.