Epithelial organ shape is generated by patterned actomyosin contractility and maintained by the extracellular matrix
Fig 8
Enzymatic degradation of Collagen IV in 96 h wing discs.
(A-D) Enzymatic degradation of the wing disc substantially changes the curvature profile of wing disc. (A’-D’) Computational simulation of acute removal of ECM and removal of actomyosin contractility components below the nuclear qualitatively match the experimental results. Wing disc was stained with CellMask for experimental imaging.