A practical application of generative adversarial networks for RNA-seq analysis to predict the molecular progress of Alzheimer's disease
Fig 6
The transition curves and heatmap of genes related to cholesterol biosynthesis and cholesterol metabolism.
(A-B) The transition curves of genes in the cholesterol biosynthesis pathway show very early increases and saturation. (C-D) Cholesterol metabolism, which is a KEGG pathway associated with cholesterol, shows a lower FDR value in P3 and a late increase of transition curves for genes such as Apoe, Abca1, and Ldlr. (E) Schematic diagram of a suggested hypothesis for mutual regulation between Aβ production and cholesterol biosynthesis. Our finding that Aβ regulates cholesterol biosynthesis is denoted by the red outlines. Other parts were constructed based on the referenced literature.