Pseudocell Tracer—A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination
Fig 1
Pseudocell Tracer, a framework for modeling cellular trajectories in complex systems.
(A) An overview of pseudotime trajectory inference. (B) Some scenarios that may obstruct pseudotime ordering. (C) Pseudocell Tracer. Given some prior knowledge about a model system, we aim to predict expression trajectories by generating pesudocells at regular intervals along a virtual cell-state axis, even though such cells may be sparsely captured in single cell profiling data.