Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes
Fig 11
Comparison of measured and estimated adult QTp intervals.
We compare the QTp intervals (see Fig 3) estimated by the computational procedure and the measured QTp intervals from [15] for different heart rates. We consider the WT case, the SQT1 case and the SQT1 case with cells exposed to 6.5 μM quinidine. The drug effect estimated by the procedure is based on measured drug effects for SQT1 hiPSC-CMs from [9]. Data used in this figure can be found in S1 Data.