Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes
Fig 5
Representation of the SQT1 mutation N588K in the IKr model.
Left panel: Steady state IKr currents obtained at different fixed values of the membrane potential divided by the currents obtained at v = 0 mV. The results obtained for the fitted WT and SQT1 IKr models are compared to corresponding data from [14]. Right panel: Comparison of the steady state inactivation gate in the WT and SQT1 models of IKr and steady state inactivation data from [14]. In the SQT1 case, the inactivation is shifted towards higher values of the membrane potential. Data used in this figure can be found in S1 Data.