Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes
Fig 3
Illustration of considered biomarkers.
Left: Illustration of the five biomarkers included in the cost function of the inversion procedure: The action potential durations (in ms) at 90% and 50% repolarization (APD90 and APD50, respectively), the maximal upstroke velocity (dvdt, in mV/ms), the action potential amplitude (APA, in mV) and the resting membrane potential (RMP, in mV). Right: Illustration of the QTp interval (in ms) computed from a pseudo-ECG waveform. The QTp interval is defined as the time from the onset of the QRS complex to the peak of the T-wave.