Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes
Fig 2
Illustration of the assumptions underlying the computational maturation approach.
1) The density of different types of ion channels (and other membrane or intracellular proteins) may differ between hiPSC-CMs and adult CMs, but the function of the individual channels is the same. In the model, the density difference is represented by the parameter λ. 2) The SQT1 mutation affects the individual IKr channels in exactly the same manner for hiPSC-CMs and adult CMs. In the model, the mutation is represented by an adjusted model for the open probability, oKr. 3) The effect of a drug on a single protein is the same for hiPSC-CMs and adult CMs. In the model, the drug effect is represented by the parameter ε.