The location of the axon initial segment affects the bandwidth of spike initiation dynamics
Fig 4
Performance of various excitatory rat cortical neuron models. We repeated the analysis of Figs 2 and 3, focusing on the “cut-off” frequency sensitivity to the soma-AIS distance (see Figs 2F and 3F) of all the 13 excitatory neuron models, as released by the Blue Brain Project. Each panel refers to a distinct cell type across cortical layers 2/3, 4, 5, and 6, and is representative of Pyramidal Cells (PC), Star Pyramidal cells (SP), Spiny Stellate neurons (SS), Thick-Tufted Pyramidal Cells (TTPC), Untufted Pyramidal Cells (UTPC), Slender Tufted Pyramidal Cells (STPC), Pyramidal Cell with Bipolar apical-like dendrites (BPC), Pyramidal Cell with Inverted apical-like dendrites (IPC), Tufted Pyramidal Cell with apical dendrites terminating in Layer 1 (TPCL1), and Tufted Pyramidal Cell with apical dendrites terminating in Layer 4 (TPCL4). The continuous traces represent logistic functions whose parameters (Table 1) have been best fitted to the simulation results. Color coding as in Fig 2.