Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection
Fig 1
Schematic of the mathematical model of SHIV dynamics with bNAb therapy.
Orange and green arrows indicate processes involved in the growth and control of infection, respectively, while magenta arrows indicate processes initiated or enhanced by bNAbs. Corresponding model equations are described in Methods. Steady state analysis of the model indicates two outcomes of the infection: chronic infection with high viremia that marks progressive disease (red filled square), typically realized in the absence of treatment, and viremic control (blue filled square), a switch to which is orchestrated by early bNAb therapy.