Template-based mapping of dynamic motifs in tissue morphogenesis
Fig 5
(A) Distribution of time difference between contraction of the two disappearing junctions in 5-cell rosettes. (B) Left: Snapshots illustrating synchronous and sequential formation of 5-cell rosettes. Right: schematics of junction dynamics. (C,D) Same as (A,B), respectively, but for growing junctions. (E) The rates of junction contraction (red) and growth (green) during the formation of 5-cell rosettes. The horizontal axis is the time before contraction completion and growth initiation (vertical dashed lines indicate a possible time gap between the two events). Average contraction rate is significantly lower than for T1-transition. (F) Schemes of a rosette (i) and a rosette hub (ii). Top: snapshots throughout the lifetime of the motif. Cell numbering allows relating cells over time. Bottom: a simplified diagram of the exemplified motif. A rosette hub (ii) initiates with the formation of a rosette, followed by an iterative process, whereby at least one cell separates from the rosette (cell #6), followed by the joining of at least one new cell (cell #4), all the while maintaining at least 4 cells surrounding the core vertex (cells #1,2,3,5). As a result, the central vertex serves as a hub for intercalating cells.