Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape
Fig 12
Combination treatment results: Scheduling.
Treatment responses (in terms of cell count) for HAP-IR combination therapies in the ‘Small’ MCTS (left) and the ‘Large’ MCTS (right). One dose of HAPs and one dose of IR are administered at various schedules. Solid and dashed lines show mean values, and the height of the ‘+’ markers show standard deviations for 10 in silico runs.