Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape
Fig 11
Monotherapy results: Oxygen histograms.
Treatment responses for HAP (left) and IR (right) monotherapies for the ‘Small’ (top) and ‘Large’ (bottom) MCTS. Histograms over cellular oxygenation levels at time T0 (monotherapy administration time) and 4 hours later are shown. Results are based on mean values from 10 in silico runs.