iDrug: Integration of drug repositioning and drug-target prediction via cross-network embedding
Fig 3
The intra-similarity distributions in drug-target domain.
(a) The intra-similarity distributions of drug pairs, the drug-drug similarities are calculated based on Tanimoto Score. (b) The intra-similarity distributions of target pairs, the target-target similarities are calculated using the Smith-Waterman algorithm on target sequences. Note that all the self-similarity values of drugs and targets have already been excluded in the histograms. For target-target similarities, we only show the similarity values within [0, 0.2] since most of them are located in this range.