Computational principles of neural adaptation for binaural signal integration
Fig 2
Input generation and parameter influences.
(A) Input generation for the model system for ILD calculation. Red line shows excitatory input from cells of the ipsilateral cochlear nucleus to LSO neurons. Blue line shows excitatory input from cells of the contralateral cochlear nucleus to MNTB neurons which are converted to inhibitory input to LSO neurons. Vertical grey dashed lines indicate measurement points of neuron’s response. (B) Model response of an LSO neuron for a default set of parameter values. Blue line shows the response rate of a single LSO neuron to stimuli as presented in (A) over interaural level difference. The ILD is determined by subtracting the level of the ipsilateral stimulus from the level of the contralateral stimulus. Inset shows membrane potentials for LSO (activity r, red) and MNTB (activity q, blue) neurons. Probing times (grey dashed lines) are chosen to ensure that both membrane potentials have reached a steady state before measuring. These states can be identified by horizontal plateaus in the display where the membrane potential is constant. (C,D) Model response for parameter values γr and κr, respectively. (C) Parameter values of γr are varied in range [0.0, 3.5] which control the strength of subtractive inhibition. (D) Model responses for different κr values in range [0.0, 14] that regulates the effect of shunting inhibition on the membrane potential. Filled areas are approximated from simulation results.