Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus
Fig 6
Simulated combined biochemical and biomechanical cartilage degradation.
Predicted combined biochemical and biomechanical fixed charge density (FCD) losses in A) intact reference model and B) injury model. Combined biochemical and biomechanical degradation shown at time t = 4 d was simulated with 1 ng/ml of exogenous interleukin-1 and with the degeneration threshold of = 50% of the maximum shear strain. This threshold was chosen to match model predictions and experimental findings.