Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus
Fig 5
Simulated biomechanical cartilage degradation.
Predicted biomechanical fixed charge density (FCD) losses in A) intact reference model and B) injury model. Biomechanical degradation shown at time t = 12 d was simulated with the degeneration threshold of = 50% of the maximum shear strain. This threshold was chosen to match model predictions and experimental findings.