Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus
Fig 2
Workflow for creation of A) biochemical, B) biomechanical and C) combined biochemical and biomechanical degradation models. Lesion geometry was based on histological findings after injurious loading. All of the mechanobiological models estimated fixed charge density (FCD) loss near and away from the lesion over time. Histology image obtained with permission from Orozco et al. [49].