Multiscale modeling of human cerebrovasculature: A hybrid approach using image-based geometry and a mathematical algorithm
Fig 4
Flowchart of vascular generation in the MRC algorithm.
The coarse-scale vasculatures for both arteries and veins are constructed in the LV1 reconstruction, where the location and geometries of the root edges are inherited from the terminal ends of the LV0 model. The fine-scale vasculatures are then generated in the LV2 reconstruction, where the generation continues from the terminal ends of the arteries and veins in the former level (LV1). The vascular subregions and SDF for the brain surface are used for the reconstructions at each level. The vascular generation algorithm at each level follows the geometry-prioritized CCO model described in this paper.