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Multiscale modeling of human cerebrovasculature: A hybrid approach using image-based geometry and a mathematical algorithm

Fig 2

Reconstruction procedure of the image-based vasculature.

(A) Sequential CT images for bolus injection of contrast media in the brain. (B) Reconstructed vessel geometries at frame numbers 5 and 16, where the venous vasculature is not yet isolated from the arterial one. (C) Isolated vessels for arteries (red) and veins (blue), where the isolation is performed semi-automatically based on a Boolean operation applied to overlapped domains between the vessel geometries at frames 5 and 16. (D) Vascular centerlines (solid line) with radii and terminal points (square symbol) obtained through a thinning process applied to the vessel geometries extracted from (C).

Fig 2

doi: https://doi.org/10.1371/journal.pcbi.1007943.g002