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In silico analysis of hypoxia activated prodrugs in combination with anti angiogenic therapy through nanocell delivery

Fig 8

Normalized drug concentrations in the tumour area over the treatment schedule for combretastatin-first treatment administered either separately or through nanocells.

The left column of plots is the full treatment schedule used in simulations, the right column is a zoomed-in picture of the final drug administration to better observe the difference in release profiles. Notice the delayed release in the nanocell administration case.

Fig 8

doi: https://doi.org/10.1371/journal.pcbi.1007926.g008