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In silico analysis of hypoxia activated prodrugs in combination with anti angiogenic therapy through nanocell delivery

Fig 2

Delivery rate from vessels as a function of the average vessel density.

Curve is described by the function . Notice that the optimal vessel delivery occurs at m = 1. As m becomes greater than 1, the delivery rate decreases, allowing for the impaired delivery due to overvascularization.

doi: https://doi.org/10.1371/journal.pcbi.1007926.g002