All-atom simulation of the HET-s prion replication
Fig 7
Representative scheme for HET-s prion propagation.
A. Propagation scheme starting from the N-terminal end of the fibril. In this process, the C-terminal rung of the converting monomer (depicted in red) is formed by templating onto the structured N-terminal rung of the fibril (shown in transparent grey). Subsequently, the N-terminal part of the converting monomer forms the second rung (depicted in blue); B. Propagation scheme starting from the C-terminal end of the fibril. In this process, the N-terminal rung of the converting monomer (depicted in blue) is formed by templating onto the structured C-terminal rung of the fibril (shown in transparent grey). Subsequently, the C-terminal part of the converting monomer forms the second rung (depicted in red).