Personalized logical models to investigate cancer response to BRAF treatments in melanomas and colorectal cancers
Fig 4
Logical model of signaling pathways around BRAF in colorectal and melanoma cancers.
Grey nodes represent input nodes, which may correspond to the environmental conditions. Blue nodes accounts for families. Light blue node represents the output of the model. Square nodes represent multi-valued variable (MEK, ERK, p70 and Proliferation). Note that Proliferation is used as the phenotypic read-out of the model.