Large scale analyses of genotype-phenotype relationships of glycine decarboxylase mutations and neurological disease severity
Fig 10
WMMS’s as a predictor of severe and attenuated disease.
[A] Average homozygous-trained WMMS for homozygous patients by disease type. [B] Average heterozygous-trained WMMS’s for heterozygous NKH patients by disease type. The WMMS is a significant predictor of attenuated (ATT) and severe disease type (SEV) for disease caused by both homozygous and compound heterozygous missense mutations. Healthy controls with COS = 0 are denoted as NONE.