PenDA, a rank-based method for personalized differential analysis: Application to lung cancer
Fig 8
Synergic effects of gene deregulation within a protein complex.
(a) Heatmap showing the distribution of gene deregulations of genes coding for the GINS complex in the ADC cohort. Patients are ordered from left to right according to an increasing number of gene deregulations within the GINS complex. The patients were separated into discrete deregulation groups of: 0 up-regulation (-), 1–3 up-regulations (+) and 4 up-regulations (+++). (b) Survival of ADC patients according to the deregulation groups defined in (a). (c) Cox regression p-values associated with different models (multivariate and univariate). Cox regression is applied on PenDA deregulation matrix (triangles) or expression matrix (ticked boxes, normalized count values). ALL corresponds to a multivariate cox model including the four genes of the GINS complex. The red line corresponds to the significance level of 0.01.