PenDA, a rank-based method for personalized differential analysis: Application to lung cancer
Fig 4
Overview of genetic deregulation in adenocarcinoma and squamous cell carcinoma.
(a) The percentage of deregulated genes in ADC (left panel) and SQCC (right panel) patients. % of up-regulated genes is indicated in red, % of down-regulated genes is indicated in blue, total % of deregulated genes (up + down) is indicated in black. Patients are ordered by increasing total number of deregulated genes. (b,c) Scatterplot of the percentage of deregulated patients for each gene in the ADC cohort (x-axis) versus deregulated patients percentage in the SQCC cohort (y-axis). Left panel (b) represents downregulation events and right panel (c) represents upregulation events. Colored points represent significant differences between ADC and SQCC cohorts (two-sided two-proportion z-test, p-value < 0.05 after Bonferroni correction for 18143 multiple testing).