Balance between asymmetry and abundance in multi-domain DNA-binding proteins may regulate the kinetics of their binding to DNA
Fig 8
Percentage of non-specific and specific binding asymmetry in zinc finger proteins (ZFPs) and their linkage with cellular abundance.
Plots of the percent non-specific asymmetry versus the percent specific asymmetry between adjacent zinc finger domains are presented for all ZFPs of length 3–6 domains (ZFP3-6, 98 proteins). The analysed ZFPs were binned into 16 bins on the basis of the percentage of their non-specific and specific asymmetry scores. The number of ZFPs (grey colour bar) in each of the bins is shown in (A). The mean cellular abundances (yellow-to-green colour bar) of all the ZFPs in each of the bins is shown in (B). This analysis was performed using σnonspec = 3 and σspec = 0.2.