Balance between asymmetry and abundance in multi-domain DNA-binding proteins may regulate the kinetics of their binding to DNA
Fig 7
Relationship between protein abundance and asymmetry.
The zinc-finger proteins (ZFPs) are divided into two groups depending on the percentage of asymmetric zinc finger pairs in each protein: symmetric zinc-finger proteins (containing <50% asymmetric pairs) and asymmetric zinc-finger proteins (containing ≥50% asymmetric pairs). This classification was performed separately for non-specific binding (on the basis of electrostatic net charge) and specific binding (on the basis of the specificity score). The mean abundance of each group is shown by the bar plot. The analysis was performed separately for zinc-finger proteins with 3 (left), 4 (middle), and 3–6 (right) zinc-finger domains.