Balance between asymmetry and abundance in multi-domain DNA-binding proteins may regulate the kinetics of their binding to DNA
Fig 5
Binding specificity in C2H2-type tandem zinc-fingers.
(A) Mean DNA binding specificity is shown for human C2H2-type tandem zinc finger proteins (ZFPs) of different lengths, comprising 3 (ZFP3) to 15 (ZFP15) zinc finger (ZF) domains. (B) The binding specificity of each zinc-finger domain for ZFPs comprising 3 (ZFP3) to 6 (ZFP6) ZF domains. The colours in each panel correspond to the five selected proteins shown in Fig 2.