Balance between asymmetry and abundance in multi-domain DNA-binding proteins may regulate the kinetics of their binding to DNA
Fig 4
Percentage of non-specific and specific binding asymmetry in zinc finger proteins (ZFPs) of different lengths.
Each dot represents a ZFP: the average percentage of asymmetric zinc finger (ZF) pairs for each length (i.e., number of ZF domains) is shown by a solid circle, with the corresponding standard deviation shown by the error bar. (A) Asymmetrical non-specific binding was considered to occur when the difference in net charge between two neighbouring ZF domains was σnonspec≥3e. (B) As a course approximation, asymmetrical specific binding was considered to occur when the difference in specificity score between two neighbouring ZF domains was σspec≥0.2.