Mechanistic model of hormonal contraception
Fig 8
Model results (solid blue line) with pdose = 0.6ng/mL and edose = 40 pg/mL. The dotted red line is the median maximum hormonal value during days 8-14 of combined hormonal treatment reported in Figure 1 and Table 3 in Mulders and Dieben [18]. These are the two low doses that did not reach total contraception when used individually. The application of both low doses though has achieved total contraception. For comparison, the normal cycling data are presented by a dashed-dotted magenta line.