Mechanistic model of hormonal contraception
Fig 5
Model results with high a dose *pdose = 1.3 ng/mL are plotted with a solid blue line, while the solid red horizontal line represents the mean maximum hormonal value resulting from the 21 day progestin treatment reported in Figure 1 and Table 3 in Obruca et al. [16] with the standard deviation represented by the horizontal dashed lines. For P4 we note a significant difference between model predictions and the data. This likely stems from the fact that in the model P4 includes both endogenous and exogenous progestin, while the data only measure the endogenous levels. We have reached a steady state here and thus total contraception. For comparison, the normal cycling data are presented by a dashed-dotted magenta line.