Mechanistic model of hormonal contraception
Fig 4
Model results with a low dose (pdose = 0.6 ng/mL) are plotted with a solid blue line, while the solid red horizontal red line denotes the mean maximum hormonal values resulting from the 21 day progestin treatment reported in Figure 1 and Table 3 in Obruca et al. [16] with the standard deviation represented by the horizontal dashed lines. The mid-cycle LH surge has been eliminated. With this dose we have reached biological contraception by preventing the LH surge, but we have not reached total contraception. For comparison, the normal cycling data are presented by a dashed-dotted magenta line.