PhANNs, a fast and accurate tool and web server to classify phage structural proteins
Fig 1
Non homologous database split—To ensure that no homologous sequences are shared between the test, validation, and training sets the sequences from each class (Major capsid proteins in this figure) were de-replicated at 40%.
In the de-replicated set, no two proteins have more than 40% identity and each sequence is a representative of a larger cluster of related proteins. The de-replicated set is then randomly partitioned into eleven equal size subsets, (1dMcp-10dMpc plus TestMpc). Those subsets are expanded by replacing each sequence with all the sequences in the cluster it represents (subsets 1DMpc-10DMpc plus TESTMpc). Analogous subsets are generated for the remaining ten classes and corresponding subsets are combined to generate the subsets used for 10-fold cross-validation and testing (1D-10D and TEST).