Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression
Fig 4
Factors distinguishing between Class I and Class II PAR mRNAs.
(A) Characteristics of Class I and Class II PAR mRNAs. (B) Sobol indices for the amplitude of L+S (i.e., total mRNA abundance). Bars with “S” on top: single Sobol indices. Bars with “T” on top: total Sobol indices. (C) Distributions of mean mRNA degradation rates for the two classes. (D) Distributions of peak phase differences between transcription and degradation for the two classes. (E) Distributions of relative amplitudes of transcription for the two classes. (F) Distributions of relative amplitudes of degradation for the two classes. (G) Distribution of mean deadenylation rates for the two classes. Results in (C-G) from 100,000 simulations with parameters randomly sampled according to Table 1. Parameter sets with ≥0.2 relative amplitude in both L+S and L/S ratio are defined as Class I, while those with <0.2 relative amplitude in L+S and ≥0.2 relative amplitude in L/S ratio are defined as Class II.