Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression
Fig 3
Distinct peak phases in deadenylases cluster transcripts by their peak phases of poly(A) tail length and long-tailed mRNA abundance.
(i) Transcription, degradation, deadenylation and polyadenylation phases evenly distributed around the clock. (ii) Transcription phases within three narrow windows at ZT 0, 8, and 16. Degradation, deadenylation and polyadenylation phases evenly distributed around the clock. (iii) Degradation phases within three narrow windows at ZT 0, 8, and 16. Transcription, deadenylation and polyadenylation phases evenly distributed around the clock. (iv) Deadenylation phases within three narrow windows at ZT 0, 8, and 16. Transcription, degradation and polyadenylation phases evenly distributed around the clock. (v) Polyadenylation phases within three narrow windows at ZT 0, 8, and 16. Transcription, degradation and deadenylation phases evenly distributed around the clock. (vi) Peak phases of transcription follow transcriptome data reported by [13]. Deadenylation phases within three narrow windows at ZT 2, 5, and 13, and polyadenylation phases within one narrow windows at ZT 3.5, based on the data from [29], while degradation phases evenly distributed around the clock. Mean rates and relative amplitudes follow Table 1 and S1 Fig.