Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression
Fig 2
Rhythmicities of poly(A) tail length and long-tailed mRNA abundance are strongly controlled by rhythmic deadenylation.
(A) Scatter plot of the peak phases of input processes versus the peak phases of L/S ratio (i.e., poly(A) length metric). (B) Sobol indices for the peak phase of L/S ratio. (C) Scatter plot of the peak phases of input processes versus the peak phases of L+S (i.e., total mRNA abundance). (D) Sobol indices for the peak phase of L+S. (E) Scatter plot of the peak phases of input processes versus the peak phases of L (i.e., long-tailed mRNA abundance). (F) Sobol indices for the peak phase of L. (A, C, E) Each scatter plot shows 10,000 data points randomly chosen from the original simulations for the sake of visual clarity. (B, D, F) Bars with âSâ on top: single Sobol indices. Bars with âTâ on top: total Sobol indices. Mean values of the Sobol indices are shown, because the variances are too small for clear visualization (S2 Fig).