Improving the coverage of credible sets in Bayesian genetic fine-mapping
Fig 5
Summary of adjusted coverage estimates and adjusted credible sets in T1D data set.
Top panel: The decrease in size of the credible set after adjustment. Bottom panel: The adjusted coverage estimates of 95% Bayesian credible sets for T1D-associated genomic regions. Black points represents regions where the credible set changed after the adjustment and the “-” values for the circled points represent the decrease in the number of variants from the standard to the adjusted 95% credible set. Blue points represent regions where the credible set did not change after the adjustment and grey points represent regions where the credible set did not need to be adjusted since the threshold (0.95) was contained in the 95% confidence interval of the conditional coverage estimate, or because the credible set already contained only a single variant.