Improving the coverage of credible sets in Bayesian genetic fine-mapping
Fig 4
A simple example to illustrate the results of the adjustment method.
(A) The absolute Z scores of the SNPs. (B) The PPs of the SNPs. (C) As in the fine-mapping procedure, variants are sorted into descending order of PP and summed. Starting with the SNP with the largest PP (far right) the cumulative sum (size) of the credible set is plotted as each SNP is added to the set. Red SNPs are those in the adjusted 90% credible set and blue SNPs are those that only appear in the original 90% credible set. The credible set formed of the red SNPs has an adjusted coverage estimate of 0.905 and the credible set formed of both the blue and red SNPs has an adjusted coverage estimate of 0.969.