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Resist or perish: Fate of a microbial population subjected to a periodic presence of antimicrobial

Fig 4

Dependence of the extinction probability p₀ on population size and antimicrobial mode of action.

The extinction probability p₀ is plotted versus carrying capacity K for the perfect biostatic drug (corresponding to Fig 1), two different concentrations of biocidal drugs yielding two different death rates (corresponding to Fig 2) and a drug with both biostatic and biocidal effects. Markers correspond to simulation results, computed over 10³ realizations. Solid lines correspond to our analytical predictions from Eqs 1 and 4, respectively, which hold for K ≪ 1/μ₁. Parameter values and initial conditions are the same as in Figs 1 and 2, respectively, and the period of alternations is T = 10³, which is in the large-period regime.

doi: https://doi.org/10.1371/journal.pcbi.1007798.g004