Ion channel noise shapes the electrical activity of endocrine cells
Fig 6
The effect of cell size in the stochastic model.
(A) Examples of the membrane potential from simulations of five different cell sizes, showing mostly spiking for the smallest cells (λ = 0.45) and gradually becoming almost complete bursting for large cells (λ = 3.16). For each trace, the y-axis ranges from −70 to 0 mV. (B) The bursting fraction as a function of the cell size based on a 10 μm cell (λ = 1) having 5 BK channels. The dashed line shows the equivalent plot for the deterministic model. (C) The bursting fraction as a function of the gBK area density for three cell sizes. Panel (B) corresponds to BF measured along the dashed vertical line in Panel (C).