Ion channel noise shapes the electrical activity of endocrine cells
Fig 4
Relative noise contributions for BK versus non-BK channels.
(A) Plot of dV/dt against V with gBK = 0.5 nS and noise only in BK channels (Ca, K and SK behave deterministically) for a short 600 ms period during which two events occur (a spike followed by a burst). The dashed line shows the entirely deterministic solution (with no noise in any channels), which corresponds to continuous spiking. The black circle labels the initial starting configuration. (B) As in (A) but with noise only in the Ca, K and SK channels (BK acts deterministically). (C) The BF-against-gBK behaviour for different sources of noise showing that, whereas non-BK noise slightly smooths out the deterministic step function, the majority of the difference between the deterministic and fully stochastic models arises from noise in the BK channels.