Ion channel noise shapes the electrical activity of endocrine cells
Fig 3
The effect on bursting of the total number of channels and the BK time constant.
(A) For gBK = 0.5 nS, corresponding to pure spiking in the deterministic model, BF gradually decreases as the total number of channels increases. However, for gBK = 0.6 nS, corresponding to pure bursting deterministically, increasing σ leads to an initially drop in BF before an increase towards BF = 1. (B) Higher values of τBK lead to less bursting as BK channels start to act more like K channels. Conversely smaller τBK, i.e. even faster acting BK channels, lead to more bursting. (C) The overall sigmoidal BF-against-gBK behaviour seen in Fig 2 is the same for other values of τBK. However, sufficiently large values of τBK only rarely lead to bursting even for very large total BK conductances.