Stochastic dynamics of Francisella tularensis infection and replication
Fig 6
Agent-based realisation compared to predicted means: First cohort of macrophages.
In a numerical realisation, N = 30 macrophages are infected, by one bacterium each, at t = 0. The red line shows the number of those macrophages surviving up to time t. The dotted red curve is NS(t), using the survival function (5). Each blue dot in the lower panel coincides with a downward step in the red line, corresponding to a macrophage rupture event. The dotted blue curve is , given by (11). Parameter values have been taken from Ref. [23]: β = 0.15 h−1, μ = 0 and δ = 0.001 h−1. Agent-based realisations are simulated making use of tau-leaping time-stepping with Δt = 0.01 h−1, M = 104, ρ = 0.01 h−1, ϕ = 2 h−1, μE = 0.01 h−1 and γ = 1 h−1.