Complementary computational and experimental evaluation of missense variants in the ROMK potassium channel
Fig 6
Tested variants on the 3D structure of ROMK.
Left, residues associated with variants tested experimentally are color-coded on the ribbon representation according to their measured phenotypes, as in Fig 3. Right, the dominant twisting deformation computed from an elastic network model of the tetramer is indicated by red arrows. K80 is positioned near the interface between the two oppositely rotating (transmembrane and cytoplasmic) regions.