Buffering and total calcium levels determine the presence of oscillatory regimes in cardiac cells
Fig 14
Solutions as a function of total calcium concentration , with calsequestrin concentration set to zero when the fast dyadic approximation is used.
We obtain the same type of structure as expected. The system can be in a monostable state, which is excitatory (low load), in an oscillatory state (intermediate load), or in a bistable state (high loads), where it usually ends in a state of open RyR and depleted SR calcium concentration.