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Buffering and total calcium levels determine the presence of oscillatory regimes in cardiac cells

Fig 3

A: Calcium traces obtained with the full subcellular model and three different values of the average calcium concentration, . B: Line-scans at different values of the load. Increasing the load, the system undergoes a transition from a low cytosolic calcium state (at ), where RyRs remain in the closed state, to spontaneous oscillations, giving rise to calcium waves (). Finally, at high calcium loads () oscillations give rise to a high cytosolic calcium state, where the RyRs remain open, resulting in SR calcium depletion.

doi: https://doi.org/10.1371/journal.pcbi.1007728.g003