An in-silico human cell model reveals the influence of spatial organization on RNA splicing
Fig 5
A) Increasing the number of nuclear speckles, results in an increase of the surface area (magenta curve) and decrease of the speckles diameter (blue curve); B) mRNA production increases as the number of speckles increases till about 50 speckles beyond which the production plateaus.
Error bars represent the standard deviations. For each condition, 20 simulation replicates were performed.